Adenosine monophosphate–activated protein kinase in diabetic nephropathy
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چکیده
منابع مشابه
Adenosine monophosphate–activated protein kinase in diabetic nephropathy
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and its pathogenesis is complex and has not yet been fully elucidated. Abnormal glucose and lipid metabolism is key to understanding the pathogenesis of DN, which can develop in both type 1 and type 2 diabetes. A hallmark of this disease is the accumulation of glucose and lipids in renal cells, resulting in oxidative and...
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Chronic hyperglycemia is the main cause of diabetic microvascular complications of the kidney and retina. Multiple theories have been proposed to explain the adverse effects of hyperglycemia, including increased flux through the polyol pathway, excessive formation of advanced glycation end-products, oxidative stress, and altered signaling pathways such as protein kinase C (PKC). This article wi...
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Heat shock protein (HSP) HSP27, HSP60, HSP70, and HSP90 are induced by cellular stresses and play a key role in cytoprotection. Both hyperglycemia and glomerular hypertension are crucial determinants in the pathogenesis of diabetic nephropathy and impose cellular stresses on renal target cells. We studied both the expression and the phosphorylation state of HSP27, HSP60, HSP70, and HSP90 in viv...
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ژورنال
عنوان ژورنال: Kidney Research and Clinical Practice
سال: 2016
ISSN: 2211-9132
DOI: 10.1016/j.krcp.2016.02.004